circRNA basic information
circBase ID: -
Name: hsa_circ_MAP3K5
Synonym: -
Host Gene: hsa-miR-22-3p
 
 
 
Disease basic information
DO ID:
 178
DO name: vascular disease
Disease details: neointimal hyperplasia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
UP
Associated gene: Tet2
Associated microRNA: hsa-miR-22-3p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

We identify circMAP3K5 as a master regulator of TET2-mediated vascular SMC differentiation. Targeting the circMAP3K5/miR-22-3p/TET2 axis may provide a potential therapeutic strategy for diseases associated with intimal hyperplasia, including restenosis and atherosclerosis.
Other information
Title:

Circular RNA CircMAP3K5 Acts as a MicroRNA-22-3p Sponge to Promote Resolution of Intimal Hyperplasia Via TET2-Mediated Smooth Muscle Cell Differentiation.

Journal: Circulation
Published: 2020/11/20
PubMed ID: 33207953