circRNA basic information
circBase ID: hsa_circ_0002768
Name: hsa_circ_MYLK
Synonym: -
Host Gene: hsa-miR-29a
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: bladder cancer cell lines (EJ, T24, 5673, BIU-87), 293T, human Umbilical Vein Endothelial Cells (HUVECs)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: VEGFA
Associated microRNA: hsa-miR-29a
Biological function: promoted cell proliferation and invasion and inhibited cell apoptosis
Molecular mechanism: contribute to EMT and the development of BC through activating VEGFA/VEGFR2 and downstream Ras/ERK signaling pathway
Survival: poor
Supported No.:
 3
Description:

CircRNA-MYLK might function as competing endogenous RNA (ceRNA) for miR-29a, which could contribute to EMT and the development of bladder carcinoma through activating VEGFA/VEGFR2 and downstream Ras/ERK signaling pathway.
Other information
Title:

Circular RNA MYLK as a competing endogenous RNA promotes bladder cancer progression through modulating VEGFA/VEGFR2 signaling pathway.

Journal: Cancer Lett
Published: 2017/7/9
PubMed ID: 28687357