circRNA basic information
circBase ID: hsa_circ_0069767
Name: hsa_circ_KIT
Synonym: -
Host Gene: hsa-miR-636
 
 
 
Disease basic information
DO ID:
 9538
DO name: multiple myeloma
Disease details: multiple myeloma
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: K-RAS
Associated microRNA: hsa-miR-636
Biological function: decreased proliferation, migration and invasion, but increased apoptosis
Molecular mechanism: miRNA sponge
Survival: better
Supported No.:
 1
Description:

Patients with high expression of circ_0069767 had longer PFS and OS. Cell function experiments showed that overexpression of circ_0069767 in MM cells led to decreased proliferation, migration and invasion, but increased apoptosis; meanwhile, knockdown of circ_0069767 caused opposite biological behaviors. Circ_0069767 by sponging miR-636 in MM cells regulates the expression of K-RAS while the K-RAS gene remained unmutated.
Other information
Title:

Effect of the Up-Regulation of Circular RNA Hsa_circ_0069767 Derived from C-KIT on the Biological Behavior of Multiple Myeloma Cells.

Journal: Cancer Manag Res
Published: 2020/11/17
PubMed ID: 33192092