circRNA basic information
circBase ID: -
Name: hsa_circ_PDK1
Synonym: -
Host Gene: hsa-miR-377-3P
 
 
 
Disease basic information
DO ID:
 4451
DO name: renal carcinoma
Disease details: renal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: 786_0, 769-P, ACHN
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NOTCH1
Associated microRNA: hsa-miR-377-3P
Biological function: Promotes RCC Cell Migration and Invasion
Molecular mechanism: Regulating the hsa-miR-377-3P-NOTCH1 Axis
Survival: -
Supported No.:
 1
Description:

CircPDK1 is aberrantly expressed in RCC and promotes the metastasis of RCC cells mainly through sponging miR-377-3P and reducing its negative regulation of NOTCH1. Thus, circPDK1 may act as a therapeutic target and biomarker for RCC.
Other information
Title:

Upregulated circPDK1 Promotes RCC Cell Migration and Invasion by Regulating the miR-377-3P-NOTCH1 Axis in Renal Cell Carcinoma.

Journal: Onco Targets Ther
Published: 2020/11/12
PubMed ID: 33173313