circRNA basic information
circBase ID: hsa_circ_0010283
Name: hsa_circ_UBR4
Synonym: -
Host Gene: hsa-miR-133a-3p
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: atherosclerosis
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PAPPA
Associated microRNA: hsa-miR-133a-3p
Biological function: circ_0010283 knockdown suppressed ox-LDL-induced proliferation, migration and invasion in HVSMCs
Molecular mechanism: modulating the hsa-miR-133a-3p/PAPPA pathway
Survival: -
Supported No.:
 3
Description:

circ_0010283 participated in ox-LDL-induced dysfunctions of HVSMCs by modulating the miR-133a-3p/PAPPA pathway, suggesting that circ_0010283 might be associated with atherosclerosis pathogenesis.
Other information
Title:

Hsa-circ_0010283 Regulates Oxidized Low-Density Lipoprotein-Induced Proliferation and Migration of Vascular Smooth Muscle Cells by Targeting the miR-133a-3p/Pregnancy-Associated Plasma Protein A Axis.

Journal: Circ J
Published: 2020/11/10
PubMed ID: 33162460