circRNA basic information
circBase ID: -
Name: hsa_circ_GLCE
Synonym: -
Host Gene: hsa-miR-587
 
 
 
Disease basic information
DO ID:
 90
DO name: degenerative disc disease
Disease details: intervertebral disc degeneration
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: STAP1
Associated microRNA: hsa-miR-587
Biological function: inhibiting the apoptosis
Molecular mechanism: target hsa-miR-587/STAP1
Survival: -
Supported No.:
 1
Description:

CircGLCE attenuates IDD by inhibiting the apoptosis of NP cells and ECM degradation through the targeting of miR-587/STAP1. CircGLCE may be a potential therapeutic target for IDD treatments.
Other information
Title:

CircGLCE alleviates intervertebral disc degeneration by regulating apoptosis and matrix degradation through the targeting of miR-587/STAP1.

Journal: Aging (Albany NY)
Published: 2020/11/8
PubMed ID: 33159017