circRNA basic information
circBase ID: -
Name: hsa_circ_CUL2
Synonym: -
Host Gene: hsa-miR-142-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: AGS, SGC-7901, MKN-45, BGC-823
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: ROCK2
Associated microRNA: hsa-miR-142-3p
Biological function: function as a tumor suppressor and regulator of cisplatin sensitivity
Molecular mechanism: through hsa-miR-142-3p/ROCK2-mediated autophagy activation
Survival: -
Supported No.:
 1
Description:

circCUL2 may function as a tumor suppressor and regulator of cisplatin sensitivity through miR-142-3p/ROCK2-mediated autophagy activation, which could be a key mechanism and therapeutic target for GC.
Other information
Title:

circCUL2 regulates gastric cancer malignant transformation and cisplatin resistance by modulating autophagy activation via miR-142-3p/ROCK2.

Journal: Mol Cancer
Published: 2020/11/7
PubMed ID: 33153478