circRNA basic information
circBase ID: -
Name: hsa_circ_FBXW7
Synonym: -
Host Gene: hsa-miR-18b-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: SW480, HCT116
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-18b-5p
Biological function: ameliorates the chemoresistance to oxaliplatin
Molecular mechanism: sponging hsa-miR-18b-5p
Survival: -
Supported No.:
 3
Description:

The circ-FBXW7 delivery by exosomes could ameliorate chemoresistance to oxaliplatin in CRC by directly binding to miR-128-3p, suggesting a promising therapeutic strategy for oxaliplatin-resistant CRC patients.
Other information
Title:

Exosomal transfer of circular RNA FBXW7 ameliorates the chemoresistance to oxaliplatin in colorectal cancer by sponging miR-18b-5p.

Journal: Neoplasma
Published: 2020/11/5
PubMed ID: 33147048