circRNA basic information
circBase ID: hsa_circ_0000043
Name: hsa_circ_PUM1
Synonym: -
Host Gene: hsa-miR-1271-5p
 
 
 
Disease basic information
DO ID:
 1380
DO name: endometrial cancer
Disease details: endometrial cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HEC-1A, HHUA
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CTNND1
Associated microRNA: hsa-miR-1271-5p
Biological function: Knockdown of circ_0000043 inhibited the progression of EC by inhibiting cell proliferation, migration, invasion and tumor growth (in vivo) and promoting apoptosis
Molecular mechanism: positively regulated CTNND1 expression by sponging hsa-miR-1271-5p
Survival: -
Supported No.:
 2
Description:

circ_0000043 positively regulated CTNND1 expression by sponging miR-1271-5p. CONCLUSION: Circ_0000043 knockdown inhibited the progression of EC by regulating miR-1271-5p/CTNND1 axis, which might provide a promising circRNA-targeted therapy for EC.
Other information
Title:

Circular RNA circ_0000043 promotes endometrial carcinoma progression by regulating miR-1271-5p/CTNND1 axis.

Journal: Arch Gynecol Obstet
Published: 2020/11/1
PubMed ID: 33128584