circRNA basic information
circBase ID: -
Name: hsa_circ_PDE4D
Synonym: -
Host Gene: hsa-miR-103a-3p
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HEK293T, SW1353
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: FGF18
Associated microRNA: hsa-miR-103a-3p
Biological function: Protects against Osteoarthritis
Molecular mechanism: Binding to hsa-miR-103a-3p and Regulating FGF18
Survival: -
Supported No.:
 2
Description:

Mechanistically, we found that circPDE4D exerted its effect by acting as a sponge for miR-103a-3p and thereby regulated FGF18 expression, which is a direct target of miR-103a-3p. In conclusion, our findings highlight a novel protective role of circPDE4D in OA pathogenesis and indicate that the targeting of the circPDE4D-miR-103a-3p-FGF18 axis might provide a potential and promising approach for OA therapy.
Other information
Title:

Circular RNA circPDE4D Protects against Osteoarthritis by Binding to miR-103a-3p and Regulating FGF18.

Journal: Mol Ther
Published: 2020/10/31
PubMed ID: 33125858