circRNA basic information
circBase ID: hsa_circ_0093996
Name: hsa_circ_TET1
Synonym: -
Host Gene: hsa-miR-492, hsa-miR-494-3p
 
 
 
Disease basic information
DO ID:
 768
DO name: retinoblastoma
Disease details: retinoblastoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Y79, WERI-Rb1
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-492, hsa-miR-494-3p
Biological function: inhibited proliferation, migration and invasion, and promoted apoptosis and cell cycle arrest in Y79 and WERI-Rb1 cells
Molecular mechanism: Targeting hsa-miR-492 and hsa-miR-494-3p through Wnt/beta-catenin Signaling Pathway
Survival: -
Supported No.:
 2
Description:

CircTET1 inhibited RB progression by sponging miR-492/miR-494-3p and inactivating the Wnt/beta-catenin pathway, which provided new insights for RB treatment.
Other information
Title:

CircTET1 Inhibits Retinoblastoma Progression via Targeting miR-492 and miR-494-3p through Wnt/beta-catenin Signaling Pathway.

Journal: Curr Eye Res
Published: 2020/10/29
PubMed ID: 33108919