circRNA basic information
circBase ID: -
Name: hsa_circ_SERPINE2
Synonym: -
Host Gene: hsa-miR-495
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: TGFBR2
Associated microRNA: hsa-miR-495
Biological function: weakens IL-1beta-caused apoptosis and extracellular matrix degradation of chondrocytes
Molecular mechanism: regulating hsa-miR-495/TGFBR2 axis
Survival: -
Supported No.:
 2
Description:

circSERPINE2 attenuated IL-1beta-caused apoptosis and extracellular matrix degradation of chondrocytes by regulating miR-495/TGFBR2 axis, indicating a new target for OA treatment.
Other information
Title:

CircSERPINE2 weakens IL-1beta-caused apoptosis and extracellular matrix degradation of chondrocytes by regulating miR-495/TGFBR2 axis.

Journal: Biosci Rep
Published: 2020/10/24
PubMed ID: 33094798