circRNA basic information
circBase ID: -
Name: hsa_circ_NFIX
Synonym: -
Host Gene: hsa-miR-212-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: A549, H1299, H1975, H1650 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ADAM10
Associated microRNA: hsa-miR-212-3p
Biological function: CircNFIX knockdown suppressed NSCLC cell viability, migration, invasion and glycolysis in vitro and hampered tumor growth in vivo
Molecular mechanism: acted as a molecular sponge of hsa-miR-212-3p
Survival: -
Supported No.:
 1
Description:

Our findings first identified that the knockdown of circNFIX, a highly expressed circRNA in NSCLC, exerted a repressive role in NSCLC malignant progression at least in part through targeting the miR-212-3p/ADAM10 axis, illuminating a novel understanding of circRNA regulation in NSCLC.
Other information
Title:

CircNFIX Acts as a miR-212-3p Sponge to Enhance the Malignant Progression of Non-Small Cell Lung Cancer by Up-Regulating ADAM10.

Journal: Cancer Manag Res
Published: 2020/10/17
PubMed ID: 33061643