circRNA basic information
circBase ID: -
Name: mmu_circ_HIPK2
Synonym: -
Host Gene: mmu-miR-485-5p
 
 
 
Disease basic information
DO ID:
 1287
DO name: cardiovascular system disease
Disease details: myocardial injury
Species: mouse
Species details: mouse
Sample type: cell line
Sample type details: mouse neonatal cardiomyocytes (MNCs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ATG101
Associated microRNA: mmu-miR-485-5p
Biological function: Accelerates Cell Apoptosis and Autophagy in Myocardial Oxidative Injury
Molecular mechanism: Sponging mmu-miR-485-5p and Targeting ATG101
Survival: -
Supported No.:
 1
Description:

circ-HIPK2 facilitates autophagy to accelerate cell apoptosis and cell death in H2O2-caused myocardial oxidative injury through the miR-485-5p/ATG101 pathway, indicating a novel therapeutic target point for patients with myocardial injury.
Other information
Title:

Circ-HIPK2 Accelerates Cell Apoptosis and Autophagy in Myocardial Oxidative Injury by Sponging miR-485-5p and Targeting ATG101.

Journal: J Cardiovasc Pharmacol
Published: 2020/10/8
PubMed ID: 33027196