circRNA basic information
circBase ID: hsa_circ_0007556
Name: hsa_circ_APP
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 10652
DO name: Alzheimer disease
Disease details: Alzheimer disease
Species: human
Species details: human
Sample type: cell line
Sample type details: HEK293, N2a cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

circAbeta-a and its corresponding translation product could potentially represent novel therapeutic targets for AD treatment. Importantly, our data point to yet another evolutionary route for potentially increasing proteome complexity by generating additional polypeptide variants using back-splicing of primary transcripts that yield circular RNA templates.
Other information
Title:

Circular RNA Encoded Amyloid Beta peptides-A Novel Putative Player in Alzheimer Disease.

Journal: Cells
Published: 2020/10/3
PubMed ID: 33003364