circRNA basic information
circBase ID: -
Name: mmu_circ_Hivep2
Synonym: -
Host Gene: mmu-miR-181a-5p
 
 
 
Disease basic information
DO ID:
 1826
DO name: epilepsy
Disease details: epilepsy
Species: mouse
Species details: mouse
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
DN
Associated gene: SOCS2
Associated microRNA: mmu-miR-181a-5p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

circHivep2 regulates microglia activation in the progression of epilepsy by interfering with miR-181a-5p to promote SOCS2 expression, indicating that circHivep2 may serve as a therapeutic tool to prevent the development of epilepsy.
Other information
Title:

CircHivep2 contributes to microglia activation and inflammation via miR-181a-5p/SOCS2 signalling in mice with kainic acid-induced epileptic seizures.

Journal: J Cell Mol Med
Published: 2020/10/2
PubMed ID: 33002329