circRNA basic information
circBase ID: hsa_circ_0005785
Name: hsa_circ_ANAPC7
Synonym: -
Host Gene: hsa-miR-578
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: uh7, Hep3B, SK-Hep1, HCCLM3
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: APRIL
Associated microRNA: hsa-miR-578
Biological function: hsa_circ_0005785 depletion could repress proliferation and metastasis of the HCC cell in vitro, lead to cell apoptosis and cell-cycle arrest, and restrain HCC cell growth in vivo
Molecular mechanism: through the hsa-miR-578/APRIL axis
Survival: poor
Supported No.:
 2
Description:

our current study revealed an oncogenic role of hsa_circ_0005785 in the tumorigenesis of HCC. Moreover, targeting to the hsa_circ_0005785/miR-578/APRIL regulatory pathway might be a promising diagnostic and therapeutic strategy for HCC clinical practice.
Other information
Title:

Upregulated hsa_circ_0005785 Facilitates Cell Growth and Metastasis of Hepatocellular Carcinoma Through the miR-578/APRIL Axis.

Journal: Front Oncol
Published: 2020/9/26
PubMed ID: 32974140