circRNA basic information
circBase ID: hsa_circ_0000142
Name: hsa_circ_CCT3
Synonym: -
Host Gene: hsa-miR-610
 
 
 
Disease basic information
DO ID:
 9538
DO name: multiple myeloma
Disease details: multiple myeloma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: KM3, H929, MM1S, U266
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: AKT3
Associated microRNA: hsa-miR-610
Biological function: enhanced MM cell proliferation, migration, invasion and suppressed cell apoptosis
Molecular mechanism: directly targeting hsa-miR-610 and positively regulating AKT3 expression
Survival: -
Supported No.:
 1
Description:

circ_0000142 functioned as a competitive endogenous RNA, directly targeting miR-610 and positively regulating AKT3 expression. In brief, circ_0000142 enhances the proliferation and metastasis of MM cells by modulating the miR-610/AKT3 axis.
Other information
Title:

Upregulation of circ_0000142 promotes multiple myeloma progression by adsorbing miR-610 and upregulating AKT3 expression.

Journal: J Biochem
Published: 2020/9/25
PubMed ID: 32970816