circRNA basic information
circBase ID: hsa_circ_0045602
Name: hsa_circ_HN1
Synonym: -
Host Gene: hsa-miR-302b-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: MKN7, HGC-27
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ROCK2
Associated microRNA: hsa-miR-302b-3p
Biological function: Circ_HN1 silencing slowed tumor growth in vivo and impeded cell proliferation migration, invasion, and facilitated cell apoptosis in GC cells in vitro
Molecular mechanism: sponged hsa-miR-302b-3p to regulate ROCK2 expression
Survival: -
Supported No.:
 4
Description:

circ_HN1 exerted an oncogenic role in GC through upregulating ROCK2 via sponging miR-302b-3p, offering evidence that circ_HN1 is a potential target for GC therapy.
Other information
Title:

Circular RNA circ_HN1 facilitates gastric cancer progression through modulation of the miR-302b-3p/ROCK2 axis.

Journal: Mol Cell Biochem
Published: 2020/9/20
PubMed ID: 32949310