circRNA basic information
circBase ID: hsa_circ_0005728
Name: hsa_circ_UBE2D2
Synonym: -
Host Gene: hsa-miR-512-3p
 
 
 
Disease basic information
DO ID:
 60081
DO name: triple-receptor negative breast cancer
Disease details: triple-negative breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: BT-549, SUM-159, MDA-MB-231, MDA-MB-468, HCC38
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CDCA3
Associated microRNA: hsa-miR-512-3p
Biological function: Knockdown of circUBE2D2 repressed cell proliferation, migration and invasion in vitro, and impeded tumor growth in vivo
Molecular mechanism: acting as a sponge of hsa-miR-512-3p to up-regulate CDCA3 expression
Survival: poor
Supported No.:
 1
Description:

CircUBE2D2 promoted TNBC progression and doxorubicin resistance through acting as a sponge of miR-512-3p to up-regulate CDCA3 expression. Targeting circUBE2D2 combine with doxorubicin might be exploited as a novel therapy for TNBC.
Other information
Title:

CircUBE2D2 (hsa_circ_0005728) promotes cell proliferation, metastasis and chemoresistance in triple-negative breast cancer by regulating miR-512-3p/CDCA3 axis.

Journal: Cancer Cell Int
Published: 2020/9/19
PubMed ID: 32944002