circRNA basic information
circBase ID: -
Name: hsa_circ_ARHGAP12
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9261
DO name: nasopharynx carcinoma
Disease details: nasopharyngeal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Immortalized normal nasopharyngeal epithelial cells (NP69), NPC cell lines (5-8F, HNE1, HNE2, HONE1, CNE2, CHE1, 6-10B, HK1, and C666-1)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: promoted NPC cell migration and invasion
Molecular mechanism: bind directly to the 3 UTR of EZR mRNA and promote its stability
Survival: -
Supported No.:
 1
Description:

circARHGAP12 was found to promote the malignant biological phenotype of NPC via cytoskeletal remodeling, thus providing a clue for targeted therapy of NPC.
Other information
Title:

CircARHGAP12 promotes nasopharyngeal carcinoma migration and invasion via ezrin-mediated cytoskeletal remodeling.

Journal: Cancer Lett
Published: 2020/9/16
PubMed ID: 32931883