circRNA basic information
circBase ID: -
Name: hsa_circ_PTCH1
Synonym: -
Host Gene: hsa-miR-485-5p
 
 
 
Disease basic information
DO ID:
 4451
DO name: renal carcinoma
Disease details: renal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: ACHN, OS-RC-2, A498, 786-O
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: MMP14
Associated microRNA: hsa-miR-485-5p
Biological function: promotes invasion and metastasis
Molecular mechanism: regulating hsa-miR-485-5p/MMP14 axis
Survival: -
Supported No.:
 1
Description:

circPTCH1 promotes RCC metastasis via the miR-485-5p/MMP14 axis and activation of the EMT process. Targeting circPTCH1 may represent a promising therapeutic strategy for metastatic RCC.
Other information
Title:

circPTCH1 promotes invasion and metastasis in renal cell carcinoma via regulating miR-485-5p/MMP14 axis.

Journal: Theranostics
Published: 2020/9/16
PubMed ID: 32929380