circRNA basic information
circBase ID: -
Name: mmu_circ_PAN3
Synonym: -
Host Gene: mmu-miR-421
 
 
 
Disease basic information
DO ID:
 936
DO name: brain disease
Disease details: ischemia reperfusion injury
Species: mouse
Species details: mouse
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: Pink1
Associated microRNA: mmu-miR-421
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

Our findings reveal a novel role for circPAN3 in modulating autophagy and apoptosis in myocardial I/R injury and the circPAN3-miR-421-Pink1 axis as a regulatory network, which might provide potential therapeutic targets for cardiovascular diseases.
Other information
Title:

CircPAN3 ameliorates myocardial ischaemia/reperfusion injury by targeting miR-421/Pink1 axis-mediated autophagy suppression.

Journal: Lab Invest
Published: 2020/9/16
PubMed ID: 32929177