circRNA basic information
circBase ID: -
Name: hsa_circ_ATP2B4
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 14557
DO name: primary pulmonary hypertension
Disease details: pulmonary arterial hypertension
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: PASMCs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: promotes hypoxia-induced proliferation and migration of pulmonary arterial smooth muscle cells
Molecular mechanism: via the hsa-miR-223/ATR axis
Survival: -
Supported No.:
 2
Description:

CircATP2B4 potentiated hypoxia-induced proliferation and migration of PASMCs through the miR-223/ATR axis. Restoration of the level of miR-223 might be an effective therapeutic method for the treatment of PAH.
Other information
Title:

CircATP2B4 promotes hypoxia-induced proliferation and migration of pulmonary arterial smooth muscle cells via the miR-223/ATR axis.

Journal: Life Sci
Published: 2020/9/15
PubMed ID: 32926932