circRNA basic information
circBase ID: -
Name: hsa_circ_ASAP1
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: N3S, N3T3rd, U251, U251T3rd
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: NRAS/MEK1/ERK1-2 signaling
Associated microRNA: -
Biological function: enhanced GBM cell proliferation and TMZ resistance
Molecular mechanism: NRAS/MEK1/ERK1-2 signaling
Survival: -
Supported No.:
 1
Description:

CircASAP1 expression was significantly upregulated in recurrent GBM tissues and TMZ-resistant cell lines. CircASAP1 overexpression enhanced GBM cell proliferation and TMZ resistance, which could be reduced by circASAP1 knockdown. Further experiments revealed that circASAP1 increased the expression of NRAS via sponging miR-502-5p. Moreover, circASAP1 depletion effectively restored the sensitivity of TMZ-resistant xenografts to TMZ treatment in vivo.
Other information
Title:

EIF4A3-induced circular RNA ASAP1 promotes tumorigenesis and temozolomide resistance of glioblastoma via NRAS/MEK1/ERK1-2 signaling.

Journal: Neuro Oncol
Published: 2020/9/15
PubMed ID: 32926734