circRNA basic information
circBase ID: -
Name: hsa_circ_CRKL
Synonym: -
Host Gene: hsa-miR-141
 
 
 
Disease basic information
DO ID:
 10283
DO name: prostate cancer
Disease details: prostate cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal prostate epithelial cell line (RWPE-1) and PCa cell lines (C4_2, DU145, LNCaP, and 22Rv1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: KLF5
Associated microRNA: hsa-miR-141
Biological function: repressed cell cycle progression, migration, invasion, and boosted apoptosis of PCa cells
Molecular mechanism: sponging hsa-miR-141
Survival: -
Supported No.:
 2
Description:

These findings revealed that circCRKL inhibited the progression of PCa through upregulating KLF5 expression by sponging miR-141, elucidating a novel regulatory pathway in PCa cells. Our research suggested an underlying circRNA-targeted therapy for PCa.
Other information
Title:

circCRKL suppresses the progression of prostate cancer cells by regulating the miR-141/KLF5 axis.

Journal: Pathol Res Pract
Published: 2020/9/13
PubMed ID: 32919302