circRNA basic information
circBase ID: hsa_circ_0024108
Name: hsa_circ_MMP1
Synonym: -
Host Gene: hsa-miR-433
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: U251, LN229
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGB3
Associated microRNA: hsa-miR-433
Biological function: promoted the proliferation and motility and impeded the apoptosis
Molecular mechanism: Targeting circMMP1/hsa-miR-433/HMGB3 signaling
Survival: poor
Supported No.:
 2
Description:

CircMMP1 promoted the progression of glioma through acting as a competitive endogenous RNA (ceRNA) of miR-433 to up-regulate HMGB3. CircMMP1 level in serum exosomes might be a potential marker for the diagnosis of glioma patients. Targeting circMMP1/miR-433/HMGB3 signaling might be a novel insight for glioma treatment.
Other information
Title:

CircMMP1 promotes the progression of glioma through miR-433/HMGB3 axis in vitro and in vivo.

Journal: IUBMB Life
Published: 2020/9/13
PubMed ID: 32918539