circRNA basic information
circBase ID: -
Name: hsa_circ_MYLK
Synonym: -
Host Gene: hsa-miR-29a
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HCC cell lines (MHCC-97H, HCC-LM3), human normal liver cell line (HL-7702)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: KMT5C
Associated microRNA: hsa-miR-29a
Biological function: Suppression of circMYLK repressed HCC cell proliferation, migration, and invasion while increasing apoptosis
Molecular mechanism: Through the miR29a/KMT5C Signaling Pathway
Survival: -
Supported No.:
 2
Description:

circMYLK promotes HCC progression by acting as a competing endogenous RNA of miR-29a, which regulates the downstream oncogene KMT5C.
Other information
Title:

Circular RNA MYLK Promotes Hepatocellular Carcinoma Progression Through the miR29a/KMT5C Signaling Pathway.

Journal: Onco Targets Ther
Published: 2020/9/10
PubMed ID: 32904604