circRNA basic information
circBase ID: mmu_circ_0001052
Name: mmu_circ_HIPK3
Synonym: -
Host Gene: mmu-miR-152-3p
 
 
 
Disease basic information
DO ID:
 114
DO name: heart disease
Disease details: cardiac fibrosis
Species: mouse
Species details: mouse
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TGF-beta2
Associated microRNA: mmu-miR-152-3p
Biological function: promoted CF proliferation, migration and phenotypic changes under hypoxia
Molecular mechanism: acted as a mmu-miR-152-3p sponge to regulate CF proliferation, migration and phenotypic transformation through TGF-beta2
Survival: -
Supported No.:
 1
Description:

These findings demonstrated that circHIPK3 acted as a miR-152-3p sponge to regulate CF proliferation, migration and phenotypic transformation through TGF-beta2, revealing that modulation of circHIPK3 expression may represent a potential target to promote the transition of hypoxia-induced CFs to myofibroblasts.
Other information
Title:

CircHIPK3 regulates cardiac fibroblast proliferation, migration and phenotypic switching through the miR-152-3p/TGF-beta2 axis under hypoxia.

Journal: PeerJ
Published: 2020/9/10
PubMed ID: 32904464