circRNA basic information
circBase ID: mmu_circ_0000491
Name: -
Synonym: -
Host Gene: mmu-miR-101b
 
 
 
Disease basic information
DO ID:
 557
DO name: kidney disease
Disease details: diabetic nephropathy
Species: mouse
Species details: mouse
Sample type: tissue, cell line
Sample type details: MES13
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: TGFbetaRI
Associated microRNA: mmu-miR-101b
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

circRNA_0000491/miR_101b/TGFbetaRI axis in ECM accumulation and fibrosis_associated protein expression levels of mesangial cells, which suggested that circRNA_0000491 may be beneficial for the development of an effective therapeutic target for DN.
Other information
Title:

A novel identified circular RNA, circ_0000491, aggravates the extracellular matrix of diabetic nephropathy glomerular mesangial cells through suppressing miR_101b by targeting TGFbetaRI.

Journal: Mol Med Rep
Published: 2020/9/10
PubMed ID: 32901868