circRNA basic information
circBase ID: -
Name: hsa_circ_EXOC6B
Synonym: -
Host Gene: hsa-miR-421
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: normal ovarian epithelial cells (IOSE80), human ovarian cancer cell lines (A2870, SKOV3, OVCAR3)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: RUS1
Associated microRNA: hsa-miR-421
Biological function: inhibited the proliferation and invasion
Molecular mechanism: upregulating RSU1 partially via sponging hsa-miR-421
Survival: -
Supported No.:
 2
Description:

we found that circEXOC6B suppressed the growth of ovarian cancer cells through upregulating RSU1 partially via sponging miR-421. Therefore, circEXOC6B might be a potential target for the treatment of ovarian cancer.
Other information
Title:

Circular RNA circEXOC6B Inhibits the Progression of Ovarian Cancer by Sponging miR-421 and Regulating RUS1 Expression.

Journal: Onco Targets Ther
Published: 2020/9/5
PubMed ID: 32884301