circRNA basic information
circBase ID: hsa_circ_0005075
Name: -
Synonym: circ_0005075
Host Gene: hsa-miR-151a-3p
 
 
 
Disease basic information
DO ID:
 0060164
DO name: pain disorder
Disease details: neuropathic pain
Species: human
Species details: human
Sample type: PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NOTCH2
Associated microRNA: hsa-miR-151a-3p
Biological function: Knockdown of circ_0005075 repressed thebehaviors of neuropathic pain including mechanical and thermal hyperalgesia._oss of circ_0005075 could repress the neuroinflammation via targeting COX-2, IL-6 and TNF-¦Á whereas inducing IL-10 in vivo.
Molecular mechanism: _irc_0005075 significantly rescued NOTCH2 expression, which could be repressed by miR-151a-3p.
Survival: -
Supported No.:
 1
Description:

we indicated that loss ofcirc_0005075relieved neuropathic pain progression by inducement of miR-151a-3p and inactivation of NOTCH2 signaling.
Other information
Title:

Circ_0005075 targeting miR-151a-3p promotes neuropathic pain in CCI rats via inducing NOTCH2 expression.

Journal: Gene
Published: 2020/8/30
PubMed ID: 32860901