circRNA basic information
circBase ID: hsa_circ_0000034
Name: hsa_circ_DHDDS
Synonym: -
Host Gene: hsa-miR-361-3p
 
 
 
Disease basic information
DO ID:
 768
DO name: retinoblastoma
Disease details: retinoblastoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human retinal epithelial cells (ARPE-19), RB cell lines (Y79, Weri-Rb1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ADAM19
Associated microRNA: hsa-miR-361-3p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 3
Description:

ADAM19 overexpression abolished the influence of miR-361-3p mimic on viability, migration, invasion, apoptosis, and EMT of RB cells. Circ_0000034 expedited RB progression through upregulating ADAM19 via sponging miR-361-3p, which indicated that circ_0000034 might a target for RB therapy.
Other information
Title:

Circular RNA has_circ_0000034 accelerates retinoblastoma advancement through the miR-361-3p/ADAM19 axis.

Journal: Mol Cell Biochem
Published: 2020/8/28
PubMed ID: 32844346