circRNA basic information
circBase ID: hsa_circ_0046599
Name: -
Synonym: Circ_0046599
Host Gene: hsa-miR-1258
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HCC cell lines (HCCLM3, Huh7), human liver epithelial cell line (THLE-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: RPN2
Associated microRNA: hsa-miR-1258
Biological function: Circ_0046599 was highly expressed in HCC tissues and cells, and its knockdown could suppress HCC cell proliferation, migration, invasion and glycolysis process.
Molecular mechanism: increasing RPN2 expression via sponging hsa-miR-1258
Survival: -
Supported No.:
 1
Description:

Our results provided new evidence that circ_0046599 could promote the progression of HCC by increasing RPN2 expression via sponging miR-1258.
Other information
Title:

Circ_0046599 Promotes the Development of Hepatocellular Carcinoma by Regulating the miR-1258/RPN2 Network.

Journal: Cancer Manag Res
Published: 2020/8/18
PubMed ID: 32801909