circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF609
Synonym: -
Host Gene: hsa-miR-342-3p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal liver cell line (LO2), HCC cell lines (LM3, Hep-3B, Huh7, HepG2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PAP2C
Associated microRNA: hsa-miR-342-3p
Biological function: Depletion of circZNF609 restrained HCC cell viability, migration and invasion while enhanced cell apoptosis.
Molecular mechanism: Upregulating PAP2C Expression via Sponging hsa-miR-342-3p
Survival: poor
Supported No.:
 2
Description:

CircZNF609 was highly expressed in HCC tissues and driven HCC progression by sponging miR-342-3p and upregulating RAP2C. This study may provide new potential therapeutic targets for HCC treatment.
Other information
Title:

Circular RNA ZNF609 Promoted Hepatocellular Carcinoma Progression by Upregulating PAP2C Expression via Sponging miR-342-3p.

Journal: Onco Targets Ther
Published: 2020/8/18
PubMed ID: 32801783