circRNA basic information
circBase ID: -
Name: mmu_circ_WBSCR17
Synonym: -
Host Gene: mmu-miR-185-5p
 
 
 
Disease basic information
DO ID:
 557
DO name: kidney disease
Disease details: diabetic nephropathy
Species: mouse
Species details: mouse
Sample type: tissue, cell line
Sample type details: human kidney 2 cells (HK-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SOX6
Associated microRNA: mmu-miR-185-5p
Biological function: Circ_WBSCR17 knockdown or SOX6 knockdown promoted cell proliferation and blocked cell apoptosis, inflammatory responses and fibrosis
Molecular mechanism: via the mmu-miR-185-5p/SOX6 regulatory axis
Survival: -
Supported No.:
 1
Description:

Circ_WBSCR17 triggered the dysfunction of HG-induced HK-2 cells, including inflammatory responses and fibrosis, which was accomplished via the miR-185-5p/SOX6 regulatory axis.
Other information
Title:

Circ_WBSCR17 aggravates inflammatory responses and fibrosis by targeting miR-185-5p/SOX6 regulatory axis in high glucose-induced human kidney tubular cells.

Journal: Life Sci
Published: 2020/8/18
PubMed ID: 32798559