circRNA basic information
circBase ID: -
Name: mmu_circ_Kcnt2
Synonym: circKcnt2
Host Gene: -
 
 
 
Disease basic information
DO ID:
 0060180
DO name: colitis
Disease details: colitis
Species: mouse
Species details: mouse
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: ILC3
Associated microRNA: -
Biological function: facilitate colitis resolution
Molecular mechanism: circKcnt2, as a nuclear circRNA, recruits the nucleosome remodeling deacetylase (NuRD) complex onto Batf promoter to inhibit Batf expression; this in turn suppresses Il17 expression and thereby ILC3 inactivation to promote innate colitis resolution
Survival: -
Supported No.:
 1
Description:

our data support a function of the circRNA circKcnt2 in regulating ILC3 inactivation and resolution of innate colitis
Other information
Title:

An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution.

Journal: Nat Commun
Published: 2020/8/17
PubMed ID: 32796851