circRNA basic information
circBase ID: -
Name: hsa_circ_UBAP2
Synonym: -
Host Gene: hsa-miR-361-3p
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: CC cell lines (C-33A, HeLa, SiHa), normal cervical epithelial cell line (End1/E6E7)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SOX4
Associated microRNA: hsa-miR-361-3p
Biological function: Knockdown of circUBAP2 suppressed cell proliferation, migration, invasion and EMT, while induced apoptosis in CC in vitro, and inhibited tumor growth and metastasis in vivo
Molecular mechanism: modulating hsa-miR-361-3p/SOX4 axis
Survival: -
Supported No.:
 1
Description:

CircUBAP2 represents a prognostic marker and contributes to tumor growth and metastasis via modulating miR-361-3p/SOX4 axis in CC, which indicates a potential therapeutic target for CC treatment.
Other information
Title:

Circular RNA UBAP2 contributes to tumor growth and metastasis of cervical cancer via modulating miR-361-3p/SOX4 axis.

Journal: Cancer Cell Int
Published: 2020/8/8
PubMed ID: 32760224