circRNA basic information
circBase ID: hsa_circ_0109291
Name: -
Synonym: -
Host Gene: hsa-miR-188-3p
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: OSCC cell lines (SCC-4, SCC-9, CAL-27, UM1, UM2), normal human oral keratinocytes (NHOK)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ABCB1
Associated microRNA: hsa-miR-188-3p
Biological function: Circ_0109291 was higher expressed in DDP-resistant OSCC tissues and cells, and its knockdown suppressed proliferation and resistance and enhanced the apoptosis of OSCC cells
Molecular mechanism: Sponging hsa-miR-188-3p to Increase ABCB1 Expression
Survival: -
Supported No.:
 2
Description:

Circ_0109291 could promote the DDP resistance of OSCC, suggesting that silenced circ_0109291 might be a key step to inhibit OSCC resistance.
Other information
Title:

Circ_0109291 Promotes Cisplatin Resistance of Oral Squamous Cell Carcinoma by Sponging miR-188-3p to Increase ABCB1 Expression.

Journal: Cancer Biother Radiopharm
Published: 2020/8/8
PubMed ID: 32758011