circRNA basic information
circBase ID: -
Name: hsa_circ_PRKCI
Synonym: -
Host Gene: hsa-miR-186-5p
 
 
 
Disease basic information
DO ID:
 5041
DO name: esophageal cancer
Disease details: esophageal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal esophageal epithelial cells (THEECs), EC cells (TE-1, KYSE410, ECA-109, KYSE450)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PARP9
Associated microRNA: hsa-miR-186-5p
Biological function: circPRKCI knockdown decreased tumor growth in vivo and constrained cell viability, colony formation, cell cycle progression, elevated cell radiosensitivity in EC cells in vitro
Molecular mechanism: modulated PARP9 expression through sponging hsa-miR-186-5p
Survival: -
Supported No.:
 1
Description:

CircPRKCI regulated cell malignancy and radioresistance through modulating the miR-186-5p /PARP9 axis in EC, which provided a might target for EC treatment.
Other information
Title:

Circular RNA PRKCI silencing represses esophageal cancer progression and elevates cell radiosensitivity through regulating the miR-186-5p/PARP9 axis.

Journal: Life Sci
Published: 2020/8/3
PubMed ID: 32739469