circRNA basic information
circBase ID: hsa_circ_0007874
Name: hsa_circ_MTO1
Synonym: -
Host Gene: hsa-miR-182-5p
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human ovarian cancer cell lines (SKOV3, OVCAR3), normal ovarian epithelial cell line (IOSE80)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: KLF15
Associated microRNA: hsa-miR-182-5p
Biological function: Inhibits the Proliferation and Invasion of Ovarian Cancer Cells
Molecular mechanism: Through the hsa-miR-182-5p/KLF15 Axis
Survival: -
Supported No.:
 2
Description:

Upregulation of circMTO1 inhibited proliferation and invasion of ovarian cancer cells while downregulation of circMTO1 promoted these processes. Mechanistically, we showed that circMTO1 sponged miR-182-5p to support KLF15 expression, eventually leading to inhibition of ovarian cancer progression.
Other information
Title:

Circular RNA MTO1 Inhibits the Proliferation and Invasion of Ovarian Cancer Cells Through the miR-182-5p/KLF15 Axis.

Journal: Cell Transplant
Published: 2020/8/1
PubMed ID: 32731816