circRNA basic information
circBase ID: -
Name: -
Synonym: circ_001842
Host Gene: hsa-miR-502-5p
 
 
 
Disease basic information
DO ID:
 4451
DO name: renal carcinoma
Disease details: renal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human RCC cell lines (Caki_1, 769_P, OSRC_2, La), human normal renal epithelial cell line hexokinase 2 (HK_2)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: SLC39A14
Associated microRNA: hsa-miR-502-5p
Biological function: augmented RCC cell proliferation, migration and invasion, as well as EMT in vitro and tumour growth in vivo
Molecular mechanism: elevate SLC39A14 expression by binding to hsa-miR-502-5p
Survival: -
Supported No.:
 1
Description:

circ_001842 in RCC pathogenesis through a miR-502-5p-dependent SLC39A14 mechanism, suggesting circ_001842 is a potential target for RCC treatment.
Other information
Title:

Circular RNA circ_001842 plays an oncogenic role in renal cell carcinoma by disrupting microRNA-502-5p-mediated inhibition of SLC39A14.

Journal: J Cell Mol Med
Published: 2020/7/31
PubMed ID: 32729666