circRNA basic information
circBase ID: hsa_circ_0139996
Name: hsa_circ_REPS2
Synonym: -
Host Gene: hsa-miR-558
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human GC cell lines (AGS, BGC-823, SGC-7901, MKN-28, MKN-45, MGC-803), a human embryonic kidney cell line (HEK293T), a human gastric epithelial cell line (GES-1)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: RUNX3/beta-catenin Signaling
Associated microRNA: hsa-miR-558
Biological function: inhibited GC cell proliferation, migration, invasion, and epithelial-mesenchymal transformation (EMT) in vitro and tumorigenesis in vivo
Molecular mechanism: via hsa-miR-558/RUNX3/beta-catenin signaling
Survival: better
Supported No.:
 1
Description:

circREPS2 suppresses the progression of GC via miR-558/RUNX3/beta-catenin signaling and is a novel promising biomarker and target for GC treatment.
Other information
Title:

Circular RNA circREPS2 Acts as a Sponge of miR-558 to Suppress Gastric Cancer Progression by Regulating RUNX3/beta-catenin Signaling.

Journal: Mol Ther Nucleic Acids
Published: 2020/7/30
PubMed ID: 32721878