circRNA basic information
circBase ID: -
Name: hsa_circ_DHX33
Synonym: -
Host Gene: hsa-miR-489-3p
 
 
 
Disease basic information
DO ID:
 4467
DO name: clear cell renal cell carcinoma
Disease details: clear cell renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: renal cancer cell lines (ACHN, Caki2, A498, Caki1, 786O), normal kidney epithelial cells line (HK2)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: MEK1
Associated microRNA: hsa-miR-489-3p
Biological function: Suppressing circDHX33 expression inhibits the proliferation and invasion of cultured cells, and suppresses tumor growth in vivo
Molecular mechanism: sponging hsa-miR-489-3p and modulating MEK1 expression
Survival: poor
Supported No.:
 1
Description:

circDHX33 plays a role in promoting ccRCC via the miR-489-3p/MEK1 axis and may serve as a novel therapeutic target for the treatment of ccRCC patients.
Other information
Title:

Circular RNA DHX33 promotes malignant behavior in ccRCC by targeting miR-489-3p/MEK1 axis.

Journal: Aging (Albany NY)
Published: 2020/7/28
PubMed ID: 32717723