circRNA basic information
circBase ID: hsa_circ_0046263
Name: hsa_circ_P4HB
Synonym: -
Host Gene: hsa-miR-133a-5p
 
 
 
Disease basic information
DO ID:
 9261
DO name: nasopharynx carcinoma
Disease details: nasopharyngeal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human NPC cell lines (6-10B, CNE-1, CNE-2, SUNE-1, 5_8F, HNE-1, C666-1), a human immortalized nasopharyngeal epithelial cell line (NP69)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IGFBP3
Associated microRNA: hsa-miR-133a-5p
Biological function: knockdown of circ-0046263 inhibited the proliferation, invasion, and migration of NPC cells
Molecular mechanism: through the hsa-miR-133a-5p/IGFBP3 axis
Survival: -
Supported No.:
 1
Description:

circ-0046263 plays a tumor-promoting role in NPC to enhance malignant behavior through the miR-133a-5p/IGFBP3 axis, which could be a potential target for NPC therapy.
Other information
Title:

Hsa_circ_0046263 functions as a ceRNA to promote nasopharyngeal carcinoma progression by upregulating IGFBP3.

Journal: Cell Death Dis
Published: 2020/7/25
PubMed ID: 32703944