circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: -
Host Gene: hsa-miR-221-3p
 
 
 
Disease basic information
DO ID:
 0070353
DO name: cataract
Disease details: age-related cataract
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human LECs (HLECs) (SRA01/04)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: PI3K/AKT pathway
Associated microRNA: hsa-miR-221-3p
Biological function: promotion of proliferation, inhibition of apoptosis, decrease of MDA level as well as increase of GSH-PX level in HLECs
Molecular mechanism: regulating hsa-miR-221-3p/PI3K/AKT pathway
Survival: -
Supported No.:
 3
Description:

circHIPK3 protected HLECs from dysfunction by regulating miR-221-3p/PI3K/AKT pathway, indicating a new insight into the pathogenesis of ARC and providing a potential therapeutic target for ARC.
Other information
Title:

Circular RNA HIPK3 regulates human lens epithelial cell dysfunction by targeting the miR-221-3p/PI3K/AKT pathway in age-related cataract.

Journal: Exp Eye Res
Published: 2020/7/19
PubMed ID: 32681842