circRNA basic information
circBase ID: -
Name: hsa_circ_RPPH1_015
Synonym: hsa_circRPPH1_015
Host Gene: hsa-miR-326
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: BC cell lines (MCF-7, MDA-MB-435, MDA-MB-231, BCAP), human normal breast cell line (HBL-100)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ELK1
Associated microRNA: hsa-miR-326
Biological function: -
Molecular mechanism: miRNA sponge
Survival: poor
Supported No.:
 1
Description:

hsa_circRPPH1_015 could bind to miRNA-326 that negatively regulates ELK1. Elevation of miRNA-326 expression resulted in inhibition of cell proliferation, colony formation, and cell invasion of MCF-7. Disturbance of miRNA-326 or overexpression of ELK1 restored the proliferation and aggressiveness in hsa_circRPPH1_015-depleted MCF-7 cells.

Other information
Title:

A Novel Circular RNA hsa_circRPPH1_015 Exerts an Oncogenic Role in Breast Cancer by Impairing miRNA-326-Mediated ELK1 Inhibition.

Journal: Front Oncol
Published: 2020/7/17
PubMed ID: 32670874