circRNA basic information
circBase ID: hsa_circ_0000527
Name: hsa_circ_FAM158A
Synonym: -
Host Gene: hsa-miR-646
 
 
 
Disease basic information
DO ID:
 768
DO name: retinoblastoma
Disease details: retinoblastoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: RB cell lines (WERI-RB-1, SO-RB50, Y79, RB355), human retinal pigment epithelial cells (ARPE-19), kidney epithelial cell (HEK293T)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: LRP6
Associated microRNA: hsa-miR-646
Biological function: contributed to RB cell proliferation, migration, invasion and suppressed cell apoptosis
Molecular mechanism: directly targeted hsa-miR-646 and positively regulated LRP6 expression
Survival: -
Supported No.:
 5
Description:

Circ_0000527 enhances the proliferation and metastasis of RB cells by modulating the miR-646/LRP6 axis.
Other information
Title:

Circ_0000527 promotes the progression of retinoblastoma by regulating miR-646/LRP6 axis.

Journal: Cancer Cell Int
Published: 2020/7/17
PubMed ID: 32669977