circRNA basic information
circBase ID: -
Name: hsa_circ_NFATC3
Synonym: -
Host Gene: hsa-miR-548I
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human cell lines (HepG2, Huh7)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-548I
Biological function: inhibit hepatoma cell proliferation, apoptosis, and migration/invasion
Molecular mechanism: sponge hsa-miR-548I to protect NFATC3 itself
Survival: better
Supported No.:
 1
Description:

both circNFATC3 and NFATC3 were shown to inhibit the phosphorylation of JNK, c-Jun, AKT, and mTOR signaling pathways. Overall, the circNFATC3 can sponge miR-548I to protect NFATC3 itself, then it regulates hepatoma cell function via the JNK, c-Jun, AKT, and mTOR signaling pathways, and the circNFATC3 can be a tumor-repressor on HCC.
Other information
Title:

circNFATC3 sponges miR-548I acts as a ceRNA to protect NFATC3 itself and suppressed hepatocellular carcinoma progression.

Journal: J Cell Physiol
Published: 2020/7/16
PubMed ID: 32667692