circRNA basic information
circBase ID: -
Name: -
Synonym: ciRS-7
Host Gene: hsa-miR-641
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: OC cell lines (SKOV3, A2780, OV2008, IGROV1, ES-2), a normal human ovarian epithelial cell line (HOSE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ZEB1 and MDM2
Associated microRNA: hsa-miR-641
Biological function: -
Molecular mechanism: miRNA sponge
Survival: poor
Supported No.:
 1
Description:

CiRS-7 serves as a competing endogenous RNA of miR-641 that promoted cell growth and metastasis in OC, via regulating ZEB1 and MDM2-mediated EMT. High ciRS-7 expression was a poor prognosis of TNM stages, lymph node metastasis status and overall survival rate in OC patients. Targeting ciRS-7/miR-641/ZEB1 or ciRS-7/miR-641/MDM2 axis may be a novel diagnostic, prognostic and therapeutic strategy for OC.
Other information
Title:

Circular RNA S-7 promotes ovarian cancer EMT via sponging miR-641 to up-regulate ZEB1 and MDM2.

Journal: Biosci Rep
Published: 2020/7/16
PubMed ID: 32667627